AOD-9604
Modified fragment of human growth hormone. 30+ peer-reviewed preclinical studies. 3-lab independent COA on every batch.
What is AOD-9604?
AOD-9604 (Anti-Obesity Drug 9604) is a modified fragment of human growth hormone corresponding to amino acids 176-191 of the hGH polypeptide. It was specifically engineered to isolate the fat-metabolizing region of growth hormone while excluding the growth-promoting effects associated with full-length hGH.
The fat-specific GH fragment has been reported to show lipolytic activity without growth-promoting effects in preclinical models. With 30+ publications, AOD-9604 has been studied in fat metabolism signaling, lipolytic pathway activation, and cartilage repair models.
Published preclinical research areas
Fat metabolism signaling
Studied in preclinical models examining adipose tissue lipolysis activation. Research explores beta-3 adrenergic receptor interaction and fat oxidation pathways independent of IGF-1 elevation.
Lipolytic activity without growth effects
A defining characteristic of AOD-9604 — preclinical studies demonstrate fat-reducing activity without the diabetogenic, growth-promoting, or IGF-1-elevating effects of full-length GH. This separation of effects is a key research focus.
Cartilage repair models
Emerging research examines AOD-9604's role in chondrocyte proliferation and cartilage matrix synthesis models, suggesting potential applications beyond fat metabolism in musculoskeletal research.
Metabolic pathway modulation
Preclinical studies explore AOD-9604's interactions with metabolic signaling cascades including glucose uptake modulation and energy expenditure pathways in adipose tissue models.
Available formulations at SMART MD
SMART MD quality standard for AOD-9604
- HPLC purity analysis — identity and purity confirmed via high-performance liquid chromatography.
- Mass spectrometry — molecular weight confirmation. Verifies correct peptide sequence.
- LAL endotoxin assay — <5 EU/mg. Bacterial endotoxin safety verification.
- 3 independent U.S. laboratories — rotating panel. No single lab relationship can compromise verification integrity.
- Lot-specific COA — publicly verifiable at smartmdpeptides.com/verify before you reach out.
Questions about this compound?
A SMART rep can walk you through the formulations we document, the lot-specific COA for any batch, purity and endotoxin data, and storage and handling requirements for your protocol. Leave your name, email, phone, and what you're researching — a rep follows up within one business day. Research use only: we do not provide dosing, administration, or human-use guidance of any kind, and nothing we send is medical advice.
AOD-9604 FAQ
What AOD-9604 formulations does SMART MD document?+
Research-grade AOD-9604 with 3-lab COA verification is available at SMART MD Peptides in a 5mg formulation. Every batch is publicly verifiable at smartmdpeptides.com/verify.
What is the purity of SMART MD's AOD-9604?+
Every AOD-9604 batch is third-party tested with a published COA. Each batch is independently verified by 3 U.S. laboratories — HPLC for purity, mass spectrometry for molecular weight, and LAL endotoxin assay for safety.
What makes AOD-9604 different from full-length GH?+
AOD-9604 is the fat-specific GH fragment (amino acids 176-191). In preclinical models, it has been reported to show lipolytic activity without the growth-promoting, diabetogenic, or IGF-1-elevating effects associated with full-length growth hormone.
Is AOD-9604 legal for research?+
AOD-9604 is legal to acquire for research purposes. It is classified as a research-use-only compound — not FDA-approved for therapeutic use, not intended for human consumption. Qualified researchers and research institutions may request documentation for preclinical laboratory research.
How should AOD-9604 be stored?+
Lyophilized (unreconstituted) AOD-9604 should be stored at -20°C, protected from light. Once reconstituted, store at 2-8°C and use within the timeframe specified on your lot-specific documentation.