Research use only. All compounds are for use by qualified researchers in controlled laboratory environments — not for human or animal consumption. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
SMARTMDResearch Series
Compounds/NAD+
RESEARCH COMPOUND

NAD+

Nicotinamide Adenine Dinucleotide

Foundational coenzyme in every living cell — declines 50% by age 50 in research models. 500+ published references across aging research.

Buy NAD+ 1000mg → Verify COA
Verified500+Published references in aging research
VerifiedCOAPublished for every batch
Verified3Independent U.S. laboratories per batch
COAPublicEvery batch verifiable by batch number — free, no account.
01 / OVERVIEW

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a foundational coenzyme present in every living cell. It is essential for over 500 enzymatic reactions — serving as a critical electron carrier in cellular energy metabolism, a substrate for DNA repair enzymes (PARPs), and an activator of sirtuins (longevity-associated proteins).

Research has demonstrated that NAD+ levels decline approximately 50% by age 50 in preclinical models — a decline associated with mitochondrial dysfunction, impaired DNA repair capacity, and accelerated cellular aging markers. This age-related decline has made NAD+ one of the most intensively studied molecules in longevity and aging research.

NAD+ is classified as a research-use-only compound in this formulation. It is not FDA-approved for any therapeutic indication. All references below describe preclinical and observational research contexts, not guaranteed human clinical outcomes.
02 / PRECLINICAL LITERATURE

Published research areas

01 / RESEARCH AREA

Cellular energy metabolism

NAD+ is the primary electron carrier in mitochondrial oxidative phosphorylation — the process that generates 90%+ of cellular ATP. Research examines how NAD+ availability directly impacts metabolic output, exercise capacity, and cellular energy production in aging models.

02 / RESEARCH AREA

DNA repair signaling

NAD+ is consumed as a substrate by PARP enzymes (Poly ADP-Ribose Polymerase) during DNA damage repair. Published research examines how declining NAD+ levels impair DNA repair capacity, leading to accumulated genomic instability in aging cellular models.

03 / RESEARCH AREA

Sirtuin activation

Sirtuins (SIRT1-7) are NAD+-dependent deacetylases linked to longevity in research models. Studies examine how NAD+ availability regulates sirtuin activity — impacting gene expression, mitochondrial biogenesis, inflammation, and stress resistance pathways.

04 / RESEARCH AREA

Mitochondrial function

Research examines NAD+'s role in maintaining mitochondrial membrane potential, electron transport chain efficiency, and mitophagy (damaged mitochondria clearance). Age-related NAD+ decline is associated with mitochondrial dysfunction in preclinical aging models.

03 / FORMULATIONS

Available formulations at SMART MD

NAD+ 1000mg
Lyophilized vial · High-purity research quantity
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04 / VERIFICATION

SMART MD quality standard for NAD+

  • HPLC purity analysis — identity and purity confirmed via high-performance liquid chromatography.
  • Mass spectrometry — molecular weight confirmation at 663.43 Da. Verifies correct NAD+ molecular structure.
  • LAL endotoxin assay — <5 EU/mg. Bacterial endotoxin safety verification.
  • 3 independent U.S. laboratories — rotating panel. No single lab relationship can compromise verification integrity.
  • Lot-specific COA — publicly verifiable at smartmdpeptides.com/verify before you order.
05 / FAQ

NAD+ FAQ

What is NAD+?+

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for over 500 enzymatic reactions. It plays critical roles in cellular energy metabolism, DNA repair, and sirtuin activation. Research shows NAD+ levels decline approximately 50% by age 50, making it one of the most studied molecules in aging research with 500+ published references.

Where can I buy research-grade NAD+?+

Research-grade NAD+ with 3-lab COA verification is available at SMART MD Peptides in a 1000mg formulation. Every batch is publicly verifiable at smartmdpeptides.com/verify.

How is NAD+ studied in research?+

NAD+ is studied across multiple research contexts: cellular energy metabolism (mitochondrial function and ATP production), DNA repair (as a PARP substrate), longevity signaling (sirtuin activation), neurodegeneration models, and age-related metabolic decline. It is administered in preclinical models via multiple routes to examine bioavailability and tissue-specific effects.

What is the difference between NAD+, NMN, and NR?+

NAD+ is the active coenzyme itself. NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are precursors — molecules that cells convert into NAD+. Research-grade NAD+ provides the active molecule directly, bypassing the conversion steps required by precursor compounds. Each has distinct research applications and bioavailability profiles.

How should NAD+ be stored?+

Lyophilized (unreconstituted) NAD+ should be stored at -20°C, protected from light and moisture. NAD+ is sensitive to heat and humidity — proper storage is critical for maintaining potency. Once reconstituted, store at 2-8°C and use within the timeframe specified on your lot-specific documentation.

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