The mitochondria peptide — targets the inner mitochondrial membrane directly. 50+ peer-reviewed preclinical studies. 99%+ HPLC-verified purity. 3-lab independent COA on every batch.
SS-31 (Elamipretide), also known as a Szeto-Schiller peptide, is a cell-permeable tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that selectively targets the inner mitochondrial membrane. It is the mitochondria peptide — targeting the inner mitochondrial membrane directly, unlike any other compound class in current research.
With 50+ preclinical publications, SS-31 has been studied extensively in models of mitochondrial inner membrane stabilization, cardiolipin binding, oxidative stress reduction, cellular energy restoration, and aging-related mitochondrial dysfunction. Its unique mechanism involves direct binding to cardiolipin on the inner mitochondrial membrane, stabilizing electron transport chain function.
SS-31 is classified as a research-use-only compound. It is not FDA-approved for any therapeutic indication. All references below describe preclinical (in vitro or animal model) research contexts, not human clinical outcomes.
Studied in preclinical models examining direct binding to cardiolipin in the inner mitochondrial membrane. Research explores stabilization of cristae structure, electron transport chain efficiency, and prevention of cytochrome c release.
Preclinical studies examine SS-31's selective interaction with cardiolipin — a phospholipid unique to the inner mitochondrial membrane. Research explores how this binding prevents cardiolipin peroxidation and maintains membrane potential.
Research examines SS-31's role in reducing mitochondrial reactive oxygen species (ROS) production at the source — by optimizing electron transport chain function rather than scavenging free radicals after they are produced.
Preclinical research explores SS-31 in age-related mitochondrial dysfunction, ATP production restoration, skeletal muscle energetics, cardiac function models, and neurodegenerative disease models involving mitochondrial impairment.
Research-grade SS-31 (Elamipretide) with 3-lab COA verification is available at SMART MD Peptides in 10mg, 25mg, and 50mg formulations. Every batch is publicly verifiable at smartmdpeptides.com/verify.
99%+ HPLC-verified purity across all SS-31 batches. Each batch is independently verified by 3 U.S. laboratories — HPLC for purity, mass spectrometry for molecular weight, and LAL endotoxin assay for safety.
SS-31 is the only research peptide that directly targets the inner mitochondrial membrane via cardiolipin binding. Unlike antioxidants that scavenge free radicals after production, SS-31 optimizes electron transport chain function to reduce ROS generation at the source. No other compound class operates by this mechanism.
SS-31 is legal to acquire for research purposes. It is classified as a research-use-only compound — not FDA-approved for therapeutic use, not intended for human consumption. Licensed researchers and physicians may acquire it for research protocols and practice-of-medicine use.
Lyophilized (unreconstituted) SS-31 should be stored at -20°C, protected from light and moisture. Once reconstituted, store at 2-8°C and use within the timeframe specified on your lot-specific documentation.
Check the COA before you buy. Compare it against any other supplier's documentation.