Found in every human cell — synthetic fragment for targeted research. 50+ preclinical studies. 99%+ HPLC-verified purity. 3-lab independent COA on every batch.
TB-500 is a synthetic fragment of Thymosin Beta 4 (TB4), a naturally occurring 43-amino-acid peptide found in virtually every human and animal cell. Thymosin Beta 4 plays a critical role in actin sequestration, cell migration, and tissue repair signaling. TB-500 replicates the active region of the full-length protein for targeted research applications.
With a molecular weight of approximately 4,963 Da, TB-500 has been the subject of 50+ preclinical studies examining its role in wound repair, tissue regeneration, anti-inflammatory signaling, cardiac tissue models, and hair follicle signaling pathways.
TB-500 is classified as a research-use-only compound. It is not FDA-approved for any therapeutic indication. All references below describe preclinical (in vitro or animal model) research contexts, not human clinical outcomes.
TB-500 is studied for its role in promoting cell migration to sites of injury. Research examines its effects on keratinocyte and endothelial cell movement, critical steps in wound closure and vascular repair models.
Preclinical literature examines TB-500 in models of muscle, tendon, and ligament tissue regeneration. Its actin-binding properties are hypothesized to facilitate cytoskeletal reorganization during tissue repair processes.
Published research explores TB-500's effects on inflammatory cytokine modulation and NF-kB pathway regulation. Studies suggest a role in reducing inflammatory responses in tissue injury models.
Emerging research examines TB-500 in cardiac tissue repair models following ischemic events, as well as hair follicle stem cell activation and anagen phase signaling in dermatological research contexts.
TB-500 is a synthetic fragment of Thymosin Beta 4 (TB4), a naturally occurring peptide found in virtually every human cell. It consists of 43 amino acids (molecular weight ~4,963 Da) and is studied for its roles in cell migration, wound repair, tissue regeneration, and anti-inflammatory signaling in preclinical models.
Thymosin Beta 4 is the full-length naturally occurring protein. TB-500 is a synthetic fragment that replicates the active region responsible for actin-binding and cell migration signaling. Researchers use TB-500 for targeted study of specific TB4 mechanisms without the complexity of the full protein.
Yes — TB-500 and BPC-157 are frequently studied together in preclinical models. Their mechanisms are complementary: TB-500 promotes cell migration while BPC-157 supports angiogenesis and tissue-repair signaling. SMART MD offers the Wolverine Blend (BPC-157 5mg + TB-500 5mg) as a pre-combined research formulation with 150+ combined references.
Research-grade TB-500 with 3-lab COA verification is available at SMART MD Peptides in 5mg and 10mg formulations, plus the Wolverine Blend (BPC-157 + TB-500). Every batch is independently verified for purity (99%+) and publicly verifiable at smartmdpeptides.com/verify.
Lyophilized (unreconstituted) TB-500 should be stored at -20°C, protected from light. Once reconstituted, store at 2-8°C and use within the timeframe specified on your lot-specific documentation.
Check the COA before you buy. Compare it against any other supplier's documentation.