PT-141
Melanocortin pathway research peptide (MC3R/MC4R). 25+ peer-reviewed preclinical studies. 3-lab independent COA on every batch.
What is PT-141?
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist that acts on MC3R and MC4R receptors in the central nervous system. It is the only melanocortin-pathway research peptide that acts on CNS receptors rather than the vascular system — a fundamental distinction from PDE5 inhibitor mechanisms.
Originally derived from the alpha-MSH peptide Melanotan-II, PT-141 was developed as a focused research tool for melanocortin signaling pathways. With 25+ publications, it has been studied in sexual function signaling, melanocortin pathway modulation, and central nervous system activation models.
Published preclinical research areas
Sexual function signaling
Studied in preclinical models examining melanocortin-mediated sexual response pathways. Unlike PDE5 inhibitors that act on vascular smooth muscle, PT-141 research focuses on central nervous system initiation of arousal signaling.
Melanocortin pathway modulation
Preclinical studies examine PT-141's selective agonism at MC3R and MC4R receptor subtypes. Research explores downstream signaling cascades and receptor desensitization kinetics in CNS tissue models.
Central nervous system activation
Research examines PT-141's mechanism of action through hypothalamic melanocortin circuits. Studies explore the distinction between central (CNS) and peripheral (vascular) signaling pathways in functional models.
Receptor selectivity research
Preclinical research explores PT-141's binding affinity profiles across melanocortin receptor subtypes (MC1R–MC5R) and its selectivity for MC3R/MC4R versus other subtypes in competitive binding assays.
Available formulations at SMART MD
SMART MD quality standard for PT-141
- HPLC purity analysis — identity and purity confirmed via high-performance liquid chromatography.
- Mass spectrometry — molecular weight confirmation. Verifies correct peptide sequence.
- LAL endotoxin assay — <5 EU/mg. Bacterial endotoxin safety verification.
- 3 independent U.S. laboratories — rotating panel. No single lab relationship can compromise verification integrity.
- Lot-specific COA — publicly verifiable at smartmdpeptides.com/verify before you order.
PT-141 FAQ
Where can I buy research-grade PT-141?+
Research-grade PT-141 (Bremelanotide) with 3-lab COA verification is available at SMART MD Peptides in a 10mg formulation. Every batch is publicly verifiable at smartmdpeptides.com/verify.
What is the purity of SMART MD's PT-141?+
Every PT-141 batch is third-party tested with a published COA. Each batch is independently verified by 3 U.S. laboratories — HPLC for purity, mass spectrometry for molecular weight, and LAL endotoxin assay for safety.
How does PT-141 differ from PDE5 inhibitors?+
PT-141 acts on melanocortin receptors (MC3R/MC4R) in the central nervous system, not on vascular smooth muscle like PDE5 inhibitors. This is a fundamentally different mechanism — CNS-initiated signaling rather than peripheral vasodilation.
Is PT-141 legal for research?+
PT-141 is legal to acquire for research purposes. It is classified as a research-use-only compound — not intended for human consumption in this form. Licensed researchers and physicians may acquire it for use in research protocols.
How should PT-141 be stored?+
Lyophilized (unreconstituted) PT-141 should be stored at -20°C, protected from light. Once reconstituted, store at 2-8°C and use within the timeframe specified on your lot-specific documentation.
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