PT-141
Melanocortin pathway research peptide (MC3R/MC4R). 25+ peer-reviewed preclinical studies. 3-lab independent COA on every batch.
What is PT-141?
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist that acts on MC3R and MC4R receptors in the central nervous system. It acts on melanocortin receptors in the central nervous system rather than on peripheral vascular tissue — a mechanistic distinction that defines its research use.
Originally derived from the alpha-MSH peptide Melanotan-II, PT-141 was developed as a focused research tool for melanocortin signaling pathways. With 25+ publications, it has been studied in melanocortin-receptor signaling, reproductive-axis pathway modulation, and central nervous system activation models.
Published preclinical research areas
Melanocortin-mediated reproductive signaling
Studied in preclinical models examining melanocortin-mediated signaling in the reproductive axis. Research focuses on central nervous system pathways rather than peripheral vasodilatory mechanisms.
Melanocortin pathway modulation
Preclinical studies examine PT-141's selective agonism at MC3R and MC4R receptor subtypes. Research explores downstream signaling cascades and receptor desensitization kinetics in CNS tissue models.
Central nervous system activation
Research examines PT-141's mechanism of action through hypothalamic melanocortin circuits. Studies explore the distinction between central (CNS) and peripheral (vascular) signaling pathways in functional models.
Receptor selectivity research
Preclinical research explores PT-141's binding affinity profiles across melanocortin receptor subtypes (MC1R–MC5R) and its selectivity for MC3R/MC4R versus other subtypes in competitive binding assays.
Available formulations at SMART MD
SMART MD quality standard for PT-141
- HPLC purity analysis — identity and purity confirmed via high-performance liquid chromatography.
- Mass spectrometry — molecular weight confirmation. Verifies correct peptide sequence.
- LAL endotoxin assay — <5 EU/mg. Bacterial endotoxin safety verification.
- 3 independent U.S. laboratories — rotating panel. No single lab relationship can compromise verification integrity.
- Lot-specific COA — publicly verifiable at smartmdpeptides.com/verify before you reach out.
Questions about this compound?
A SMART rep can walk you through the formulations we document, the lot-specific COA for any batch, purity and endotoxin data, and storage and handling requirements for your protocol. Leave your name, email, phone, and what you're researching — a rep follows up within one business day. Research use only: we do not provide dosing, administration, or human-use guidance of any kind, and nothing we send is medical advice.
PT-141 FAQ
What PT-141 formulations does SMART MD document?+
Research-grade PT-141 (Bremelanotide) with 3-lab COA verification is available at SMART MD Peptides in a 10mg formulation. Every batch is publicly verifiable at smartmdpeptides.com/verify.
What is the purity of SMART MD's PT-141?+
Every PT-141 batch is third-party tested with a published COA. Each batch is independently verified by 3 U.S. laboratories — HPLC for purity, mass spectrometry for molecular weight, and LAL endotoxin assay for safety.
What receptor pathway does PT-141 act on?+
PT-141 is a melanocortin receptor agonist with selectivity for MC3R and MC4R. Preclinical research examines central nervous system signaling through these receptors rather than peripheral vascular mechanisms. This is a fundamentally different mechanism — CNS-initiated signaling rather than peripheral vasodilation.
Is PT-141 legal for research?+
PT-141 is legal to acquire for research purposes. It is classified as a research-use-only compound — not intended for human consumption in this form. Qualified researchers and research institutions may request documentation for preclinical laboratory research.
How should PT-141 be stored?+
Lyophilized (unreconstituted) PT-141 should be stored at -20°C, protected from light. Once reconstituted, store at 2-8°C and use within the timeframe specified on your lot-specific documentation.